STIM1相关论文
目的:糖尿病是全球常见的代谢性疾病。糖尿病的发生伴随着血管平滑肌功能障碍,与细胞内Ca2+调控异常有关。而STIM1与肌浆网（SR）内Ca2......
目的:血管平滑肌收缩和舒张功能异常是多种心血管疾病的重要病理变化,血管舒缩主要依赖于细胞质中Ca2+浓度变化。在血管平滑肌细胞......
目的STIM1在多种疾病的发生发展中扮演着重要角色,本文拟探讨STIM1在低氧和野百合碱诱导的两种大鼠肺动脉高压（Pulmonary arterial ......
第一部分血小板活化参与主动脉中膜退行性变研究意义:主动脉中膜退行性变（AMD）是主动脉瘤（AA）和主动脉夹层（AD）的共同病理学基础。主动脉......
钙释放激活钙调节蛋白1(calcium release-activated calcium modulator 1，n ORAI1)基因编码基质相互作用分子1(stromal interac......
目的 探讨杆状体肌病的临床特点、肌肉病理改变和基因突变特点.方法 收集2例儿童杆状体肌病先证者临床资料,包括病史、体格检查、......
目的:特发性脊柱侧凸为生长发育期间原因不明的脊柱侧凸,好发于青少年。脊柱侧凸不但可以造成患者脊柱的塌陷、疼痛、以及畸形,严......
研究背景:甲基苯丙胺（methamphetamine,METH）,俗称“冰毒”,与儿茶酚胺类神经递质结构极其相似,是一种新型苯丙胺类精神兴奋剂,对全......
钙池操纵性钙内流(store-operated Ca2+entry,SOCE)是由基质相互作用分子(stromal interaction molecules,STIM)、钙释放激活钙通......
STIM1 Deficiency Potentiates Hepatocellular Carcinoma Metastasis via Reprogramming Glucose and Lipid
Objective Metastasis is the leading cause of death of hepatocellular carcinoma(HCC)patients,and epithelial-mesenchymal t......
Stim1 and Orai1 mediated store-operated calcium entry is critical for angiotensin Ⅱ-induced vascular
Atherosclerosis is one of the most common diseases in developed and developing countries.The proliferation of vascular s......
Calcium signaling plays a critical role in regulating various physiological processes.Ca2+ signals can be generated in d......
TRPP2 physically associates with STIM1: the role in store operated Ca2+ entry to regulate blood vess
Rationale: Polycystin-2 (TRPP2) as a Ca2+ permeable nonselective cationic channel executes crucial physiological functio......
Attenuated mesangial cell proliferation related to store-operated Ca2+ entry in aged rat: the role o
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Elevated Expression of Plasma Membrane Ca2+ channel Orai1 and Intracellular Ca2+ Oscillations Contri
Objective: Largely due to the fact that most of patients suffering from ESCC are diagnosed at advanced states, the 5-yea......
Attenuated store-operated Ca2+ entry in vascular smooth muscle cells of aged rat:the role of TRPC1,S
Store-operated calcium entry (SOCE) is a general property in various cell types usually contributing to Ca2+ influx resp......
Attenuated store-operated Ca2+ entry in mesangial cells of aged rat:the role of TRPC1,STIM1 and Orai
Store-operated calcium entry (SOCE) is mediated through the specific plasma membrane channels in response to the depleti......
2-Aminoethyldiphenyl borate (2-APB) is the most commonly used pharmacological agent in the study of calcium release-acti......
目的探讨黄芩苷对脂多糖（LPS）诱导的H9C2心肌细胞凋亡的保护作用及可能机制。方法培养H9C2心肌细胞，分为正常组、黄芩苷组（10 μmol/L......
A stromal interaction molecule1 variant up-regulates matrix metalloproteinase-2 expression by streng
Very recent studies hold promise to reveal the role of stromal interaction molecule 1 (STIM1) in non-store-operated ......
Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferatio......
目的应用RNA干扰抑制肺动脉平滑肌细胞(pulmonary aretery smooth muscle cells,PASMCs)基质交感分子1(stromal interaction molec......
Silence of STIM1 attenua=tes the proliferation and migration of EPCs after vascular injury and its m
Objective:To investigate the effect of stromal interaction molecule 1(STIM1) knockdown on the proliferation and migratio......
Objective:To examine the role of store-operated calcium entry (SOCE) and stromal interaction molecule 1 (STIM1) in survi......
高血压是最常见的慢性疾病,它所引起的心、脑和肾等靶器官的损害,可增加冠心病、卒中等心脑血管疾病的发生率,给人类带来非常大的......
研究背景:甲基苯丙胺(methamphetamine,METH)是一种新型合成毒品,因其外观形似冰,故俗称“冰毒”。METH滥用具有多器官功能损害作......
由传染性法氏囊病病毒（Infectious bursal disease virus,IBDV）导致的传染性法氏囊病（Infectious bursal disease,IBD）是一种急性、高......
学位
背景铅是一种极难被降解而且半衰期长的环境污染物,在人体有一定的生物蓄积作用,易对人体造成各种慢性损伤。已知铅的神经毒性机制......
目的:探讨下调Orai1对急性脑梗死大鼠神经功能的保护作用及可能机制。方法:将60只雄性SD大鼠随机分为假手术组(sham)、模型组(mode......
目的探讨不同浓度姜黄素诱导人肺腺癌A549细胞凋亡中Orai1和STIM1mRNA水平的改变。方法 A549细胞分别暴露于5、10、15、20、25和30......
目的 研究基质相互作用分子1 (stromal interaction molecule 1,STIM1)在海人酸(Kainic acid, KA)致痫大鼠大脑皮质中的表达变化,......
目的探讨血小板中钙离子感受蛋白基质相互作用因子1(STIM1)蛋白在急性缺血性脑卒中的表达以及其与脑梗死发作严重程度和预后的相关......
前列腺癌作为威胁男性健康最普遍多发的癌症，其发病率以每年10％的速度增加。SOCE(store-operated Ca2+entry)是细胞内维持Ca2+平衡的......
Objective:Stromal interaction molecule 1 (STIM 1) overexpression has been reported to play an important role in progress......
目的：研究在甲状腺癌细胞内外钙离子浓度改变时STIM1对SW579细胞的影响及其可能机制。方法用病毒转染法将带有STIM1‐YFP荧光探针的......
目的:探究STIM1对骨肉瘤细胞143B增殖和转移的作用及其具体机制研究。方法:使用shRNA构建STIM1敲减的143B稳转细胞株;通过实时荧光......
目的探索STIM1基因在人下咽癌细胞系Fa Du中的表达情况及其表达沉默后对细胞凋亡的影响。方法培养人下咽癌Fa Du细胞,根据不同慢病......
目的探讨钙感受器STIM1在小鼠主动脉平滑肌收缩反应中的作用。方法采用Cre-lox重组技术制备平滑肌特异性STIM1敲除小鼠(sm-STIM1-K......
目的:探讨Stim1在骨肉瘤组织和细胞中的表达水平及与顺铂耐药性的关系。方法:采用免疫组织化学染色检测了50例骨肉瘤患者的肿瘤组......
目的探讨基质相互作用分子1（STIM1）在高低转移性的乳腺癌细胞中的表达差异以及对钙库调节钙内流（SOCE）的影响。方法选取常见的高转移性......
目的:观察益气活血方联合PI3K抑制剂Wortmannin对大鼠体外血小板聚集率的影响。方法:高剂量、中剂量、低剂量益气活血方(0.2g·......
目的探讨抑制容量性钙内流（CCE）对胶质瘤U87细胞侵袭及迁移力的影响。方法采用免疫印迹（Western blot）检测基质相互作用分子1（STIM1）RNA......
目的：探讨基质相互作用分子1（stromal interaction molecule 1,STIM1）在宫颈癌中的表达及其与VEGF的相关性。方法：收集20例宫颈癌患者......
【摘要】 钙离子在细胞生存进程中起着至关重要的作用，例如细胞内信号传导，蛋白质折叠，酶的活化和程序性细胞死亡的启动。基质交感分......
Objective: Stromal interaction molecule 1(STIM1) overexpression has been reported to play an important role in progressi......
